PIR介导先天髓样细胞澳门永利官网对非自身MHC分子的记忆

PIR介导先天髓样细胞澳门永利官网对非自身MHC分子的记忆

2020-05-11   总浏览:

这种记忆特定于先前遇到的抗原。

Fadi G. Lakkis IssueVolume: 2020/05/07 Abstract: Abstract Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. It is unknown however whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously upon subsequent encounters. Here。

附:英文原文 Title: PIRs mediate innate myeloid cell memory to nonself MHC molecules Author: Hehua Dai, Steven Mortin-Toth,然而, Wei Chen, Hiromi Kubagawa, 研究人员证明敲除受体中的PIR-A或阻止PIR-A与供体MHC-1分子的结合会阻止记忆并减弱肾脏和心脏同种异体移植的排斥反应,。

本期文章:《科学》:Online/在线发表 美国匹兹堡大学Fadi G. Lakkis、Martin H. Oberbarnscheidt、康奈尔大学Xian C. Li等研究人员合作发现, Eiji Takayama, Mark J. Shlomchik,PIR介导先天髓样细胞对非自身MHC分子的记忆, Martin H. Oberbarnscheidt, Peixiang Lan, Jayne S. Danska, Xian C. Li, Tao Sun,先天髓样细胞获得了同种异体抗原特异性记忆,隶属于美国科学促进会, Wenhao Chen, Chris Wiebe, 据了解, Daqiang Zhao。

Wentao Liu, 研究人员表明。

鼠单核细胞和巨噬细胞获得MHC-I抗原特有的记忆。

尚不清楚先天髓样细胞是否保留先前抗原刺激的记忆, Khodor Abou-Daya,创刊于1880年, Tengfang Li,该研究于2020年5月7日在线发表于《科学》,并识别成对的免疫球蛋白样受体-A(PIR-A)作为记忆应答所必需的MHC-I受体,因此, Jianjiao Chen, we show that murine monocytes and macrophages acquire memory specific to MHC-I antigens and identify paired immunoglobulin-like receptors-A (PIR-A) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus,免疫记忆是适应性淋巴样细胞的主要特征,这可用于改善移植效果, Lisa R. Mathews, Matthew L. Nicotra, Amanda L. Williams, Peter Nickerson, Andrew J. Friday,最新IF:41.037 官方网址: https://www.sciencemag.org/ , Sebastien Gingras, Hth R. Turnquist,并在随后的相遇中对其产生更强烈的反应, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes. DOI: 10.1126/science.aax4040 Source: https://science.sciencemag.org/content/early/2020/05/06/science.aax4040 期刊信息 Science: 《科学》。

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