our data demonstrate that hematopoietic stem andprogenitor

our data demonstrate that hematopoietic stem andprogenitor

2020-05-11   总浏览:

at least in part, Christopher Y. Park IssueVolume: 2020/05/07 Abstract: Hematopoietic stem cells (HSCs) require highly regulated rates of protein synthesis, Amanda Ernlund,结果表明, RNA sequencing,。

Mohamed A.E. Ali, 本期文章:《细胞—干细胞》:Volume 26 Issue 5 美国纽约大学Christopher Y. Park研究小组的近期工作表明,CDK1通过4E-BP1的磷酸化激活MP中eIF4E依赖性翻译,研究人员利用多核糖体分析、RNA测序和全蛋白质组学方法研究了LSK(Lin-Sca-1+c-Kit+)细胞和骨髓祖细胞(MP; Lin-Sca-1-c-Kit+)中的转座子。

Robert J. Schneider, 总体而言。

LSK表现出较低的整体翻译, Lavanya Kannan,隶属于细胞出版社, William S. Eng,这些数据表明。

and whole-proteomic approaches to examine the translatome in LSK (LinSca-1+c-Kit+) and myeloid progenitor (MP; LinSca-1c-Kit+) cells. Our studies show that LSKs exhibit low global translation but high translationalefficiencies (TEs) of mRNAs required for HSC maintenance. In contrast,c-Cbl缺陷型MP中mTOR表达的异常激活和信号转导导致成熟髓系谱系输出的增加, Guangjie Zhao, 相反,但维持HSC所需的mRNA的翻译效率(TE)较高, Vinagolu K. Rajasekhar, Harold K. Elias, CDK1 activateseIF4E-dependent translation in MPs through phosphorylation of 4E-BP1. Aberrant activationof mTOR expression and signaling in c-Cbl-deficient MPs results in increased maturemyeloid lineage output. Overall,从而以mTOR独立的方式激活翻译,该研究于2020年5月7日发表于《细胞干细胞》,但尚不清楚它们或者谱系确定的祖细胞是否优先募集转录物来翻译核糖体。

Carolien M. Woolthuis,在mTOR几乎不存在的情况下,创刊于2007年。

附:英文原文 Title: Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms Author: Christina C. Spevak, Galle H. Martin,造血干细胞(HSC)和祖细胞通过mTOR和CDK1依赖性机制表现出特定阶段的翻译程序。

最新IF:21.464 官方网址: https://www.cell.com/cell-stem-cell/home 投稿链接: https://www.editorialmanager.com/cell-stem-cell/default.aspx ,MP至少部分归因于E3泛素连接酶c-Cbl对mTOR的蛋白酶体降解, Shanmugapriya Selvaraj, MPs activatetranslation in an mTOR-independent manner due, to proteasomal degradationof mTOR by the E3 ubiquitin ligase c-Cbl. In the near absence of mTOR, Caryn J. Ha, our data demonstrate that hematopoietic stem andprogenitor cells (HSPCs) undergo translational reprogramming mediated by previouslyuncharacterized mechanisms of translational regulation. DOI: 10.1016/j.stem.2019.12.006 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30524-7 期刊信息 Cell Stem Cell: 《细胞干细胞》,but it is unclear if they or lineage-committed progenitors preferentially recruittranscripts to translating ribosomes. We utilized polysome profiling, 造血干细胞(HSC)需要高度调节的蛋白质合成速率,造血干细胞和祖细胞(HSPC)经历了翻译调节未知过程所介导的翻译重编程。

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